For me it was World of Warcraft, hands down. I loved that game! God (and Blizzard) only know how many literal weeks, maybe months, I've spent playing that game. I grew up loving Blizzard's games, and they didn't disappoint - until Burning Crusade (imo). I quit playing WoW a few months ago after more than 2 and a half years of playing. I haven't bought the new xpac yet, but I've thought about it.
Right now, I'm playing a lot of TF2 and Fallout 3.